Article
Biosynthesis of desosamine: construction of a new macrolide carrying a genetically designed sugar moiety.
Organic letters - 15 Jul 1999
Borisova S A, Zhao L, Sherman D H, Liu H W
Abstract excerpt
[formula: see text] The appended sugars in macrolide antibiotics are indispensable to the biological activities of these important drugs. In an effort to generate a set of novel macrolide derivatives, we have created a new analogue of methymycin and neomethymycin, antibiotics produced by Streptomyces venezuelae. This analogue 15 carrying a different sugar, D-quinovose, instead of D-desosamine, was constructed by...
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