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Article

Combinatorial biosynthesis and antibacterial evaluation of glycosylated derivatives of 12-membered macrolide antibiotic YC-17.

Journal of biotechnology - 20 Oct 2013

Shinde Pramod B, Han Ah Reum, Cho Jaeyong, Lee So Ra, Ban Yeon Hee, Yoo Young Ji, Kim Eun Ji, Kim Eunji, Song Myoung-Chong, Park Je Won, Lee Dong Gun, Yoon Yeo Joon

Abstract excerpt

Expression plasmids carrying different deoxysugar biosynthetic gene cassettes and the gene encoding a substrate-flexible glycosyltransferase DesVII were constructed and introduced into Streptomyces venezuelae YJ003 mutant strain bearing a deletion of a desosamine biosynthetic (des) gene cluster. The resulting recombinants produced macrolide antibiotic YC-17 analogs possessing unnatural sugars replacing native...

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PMID: 23770075
DOI: 10.1016/j.jbiotec.2013.05.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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