Article
Shorter CAG repeat length in the androgen receptor gene is associated with more aggressive forms of breast cancer.
Breast cancer research and treatment - 1 Jan 2000
Yu H, Bharaj B, Vassilikos E J, Giai M, Diamandis E P
Abstract excerpt
The androgen receptor (AR) is a transcription factor mediating the action of androgens. The AR gene is localized on chromosome X and it contains a series of CAG trinucleotide repeats. The length of the CAG repeats varies among individuals and this polymorphism is believed to be related to AR transcriptional activity. Studies have shown that fewer CAG repeats are associated with an increased risk as well as more...
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