Article
Androgen receptor gene CAG repeats, estrogen exposure status, and breast cancer susceptibility.
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) - 1 Aug 2008
Wu Mei-Hsuan, Chou Yu-Ching, Yu Cheng-Pung, Yang Tsan, You San-Lin, Chen Chien-Jen, Sun Chien-An
Abstract excerpt
The length of a polymorphic CAG repeat in exon 1 of the androgen receptor (AR) is inversely correlated with AR transactivation activity. As heightened androgenic stimulation may oppose breast cell proliferation, which is mediated by AR, we examined whether AR-CAG repeat lengths are related to breast cancer susceptibility. A nested case-control study of 88 newly diagnosed cases of breast cancer between 1992 and...
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