Article
Hybrid anthracyclines from a genetically engineered Streptomyces galilaeus mutant.
The Journal of organic chemistry - 19 May 2000
Kunnari T J, Ylihonko K P, Klika K D, Mäntsälä P I, Hakala J M
Abstract excerpt
The genetic engineering of antibiotic-producing Streptomyces strains is an approach that is emerging and ready to become established as a successful methodology in developing analogues of the original, pharmaceutically important, natural products obtained from the organisms. The current report highlights this succes by demonstrating the high-level production of novel anthracyclines. The biosynthetic pathways of...
Topics
- Antibiotics, Antineoplastic
- Carbohydrate Sequence
- Fermentation
- Genetic Engineering
- Magnetic Resonance Spectroscopy
- Molecular Sequence Data
- Mutation
- Spectrophotometry, Ultraviolet
- Streptomyces