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Article

Parallel Pathways and Alternative Macrocyclizations in the Biosynthesis of Largimycins by Cytochrome P450 Minus Mutants of Streptomyces argillaceus.

Journal of natural products - 22 May 2026

Becerril Adriana, Pérez-Victoria Ignacio, Martín Jesús, Salas José A, Reyes Fernando, Méndez Carmen

Abstract excerpt

Largimycins are a recently discovered group of hybrid nonribosomal peptide-polyketide compounds belonging to the leinamycin family of natural products. They are produced in Streptomyces argillaceus by the lrg biosynthetic gene cluster, which includes three cytochrome P450 encoding genes. By characterizing the compounds accumulated by mutants lacking these three genes, we have determined their essential roles in...

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Identifiers

PMID: 42095415
DOI: 10.1021/acs.jnatprod.6c00240
PMCID: PMC13200230

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