Article
A gene cluster involved in nogalamycin biosynthesis from Streptomyces nogalater: sequence analysis and complementation of early-block mutations in the anthracycline pathway.
Molecular & general genetics : MGG - 23 May 1996
Ylihonko K, Tuikkanen J, Jussila S, Cong L, Mäntsälä P
Abstract excerpt
We have analyzed an anthracycline biosynthesis gene cluster from Streptomyces nogalater. Based on sequence analysis, a contiguous region of 11 kb is deduced to include genes for the early steps in anthracycline biosynthesis, a regulatory gene (snoA) promoting the expression of the biosynthetic ge...
Topics
- Amino Acid Sequence
- Animals
- Anthracyclines
- Base Sequence
- Cloning, Molecular
- DNA, Bacterial
- Gene Expression Regulation, Bacterial
- Genes, Bacterial
- Genes, Regulator
- Genetic Complementation Test
- Molecular Sequence Data
- Molecular Structure
- Multienzyme Complexes
- Multigene Family
- Mutation
- Nogalamycin
- Open Reading Frames
- Proteins