Article
The cytochrome P450 2D6 (CYP2D6) gene polymorphism among breast and head and neck cancer patients.
Clinica chimica acta; international journal of clinical chemistry - 1 Jun 2000
Topić E, Stefanović M, Ivanisević A M, Petrinović R, Curcić I
Abstract excerpt
The prevalence of CYP2D6*3 and CYP2D6*4 alleles in normal controls and cancer patients was studied using the reliable PCR-SSCP method. In the control group (n=144), four subjects (2.8%) were found to carry CYP2D6*3 allele (heterozygote), while 30 (20.8%) subjects carried CYP2D6*4 allele (18.8% heterozygotes, 2.1% homozygotes). One (1.3%) of the breast cancer (BC) patients (n=76) carried CYP2D6*3 allele, but 24...
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