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Article

Genetic variants of CYP2D6 gene and cancer risk: a HuGE systematic review and meta-analysis.

Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2012

Zhou Li-Ping, Luan Hong, Dong Xi-Hua, Jin Guo-Jiang, Man Dong-Liang, Shang Hong

Abstract excerpt

OBJECTIVE: Genetic polymorphisms in metabolic enzymes are associated with numerous cancers. A large number of single nucleotide polymorphisms (SNPs) in the CYP2D6 gene have been reported to associate with cancer susceptibility. However, the results are controversial. The aim of this Human Genome Epidemiology (HuGE) review and meta-analysis was to summarize the evidence for associations. METHODS: Studies focusing...

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PMID: 22994728
DOI: 10.7314/apjcp.2012.13.7.3165

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