Article
Dopamine D5 receptor agonist high affinity and constitutive activity profile conferred by carboxyl-terminal tail sequence.
The Journal of biological chemistry - 4 Aug 2000
Demchyshyn L L, McConkey F, Niznik H B
Abstract excerpt
The mammalian dopamine D1-like receptor gene family is comprised of two members, termed D1/D1A and D5/D1B. In an attempt to define the role of the carboxyl terminal (CT) tail in the expression of D5 subtype-specific pharmacological and constitutive activity profiles, we examined a series of D5 receptor chimeras in which only the CT tail was swapped with corresponding sequences encoding human/vertebrate D1-like...
Topics
- Amino Acid Sequence
- Binding, Competitive
- Conserved Sequence
- Cyclic AMP
- Dopamine Agonists
- Dopamine Antagonists
- Humans
- Ligands
- Mutation
- Peptide Fragments
- Receptors, Dopamine D1
- Receptors, Dopamine D5
- Recombinant Fusion Proteins
- Sequence Deletion