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Article

Probing the constitutive activity among dopamine D1 and D5 receptors and their mutants.

Methods in enzymology - 1 Jan 2010

Plouffe Bianca, D'Aoust Jean-Philippe, Laquerre Vincent, Liang Binhui, Tiberi Mario

Abstract excerpt

Dopamine D1 and D5 receptors are prototypical cell-surface seven-transmembrane (TM) G protein-coupled receptors (GPCRs) mediating elevation of intracellular cAMP levels. The high level of constitutive activity of D5 receptor mediating intracellular cAMP production is one of the functional hallmarks distinguishing the closely related D1-like dopaminergic subtypes (D1 and D5). D1-like subtypes share over 80%...

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PMID: 21036239
DOI: 10.1016/B978-0-12-381298-8.00016-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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