Dopamine D1B receptor chimeras reveal modulation of partial agonist activity by carboxyl-terminal tail sequences.

doi:10.1046/j.1471-4159.1998.71062593.x

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Article

Dopamine D1B receptor chimeras reveal modulation of partial agonist activity by carboxyl-terminal tail sequences.

Journal of neurochemistry - 1 Dec 1998

Sugamori K S, Scheideler M A, Vernier P, Niznik H B

Abstract excerpt

NNC 01-0012, a second-generation benzazepine compound, pharmacologically differentiates multiple vertebrate D1 receptor subtypes (D1A, D1B, D1C, and D1D) and displays high selectivity and affinity for dopamine D1C receptors. Functionally, whereas NNC 01-0012 acts as a full or poor antagonist at D...

Topics

Animals
Benzazepines
Binding, Competitive
COS Cells
Chimera
Cyclic AMP
Dopamine Antagonists
Ligands
Mutation
Receptors, Dopamine D1
Receptors, Dopamine D5

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