Article
Allele-specific regulation of matrix metalloproteinase-12 gene activity is associated with coronary artery luminal dimensions in diabetic patients with manifest coronary artery disease.
Circulation research - 12 May 2000
Jormsjö S, Ye S, Moritz J, Walter D H, Dimmeler S, Zeiher A M, Henney A, Hamsten A, Eriksson P
Abstract excerpt
Both the processes of atherosclerosis and plaque rupture are indicated to be influenced by matrix metalloproteinase (MMP) activity. We therefore searched for common functional variation in the matrix metalloelastase (MMP-12) gene locus that may be implicated in coronary artery disease. Single-strand conformation polymorphism analysis of DNA from healthy individuals detected a common polymorphism within the MMP-12...
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