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Article

Genetic variability of matrix metalloproteinase genes in cardiovascular disease.

Current topics in medicinal chemistry - 1 Jan 2012

Papageorgiou Nikolaos, Tousoulis Dimitris, Hatzis George, Briasoulis Alexandros, Androulakis Emmanuel, Giolis Anastasios, Siasos Gerasimos, Latsios George, Vogiatzi Georgia, Tentolouris Costas, Stefanadis Christodoulos

Abstract excerpt

It is well established that matrix metalloproteinases (MMPs) contribute to the degradation of the extracellular matrix of coronary plaque and contribute to the thinning of the fibrous cap. As a result, the atheromatous plaque becomes unstable and prone to rupture with consequent clinical manifestations including acute coronary syndromes. Moreover, genetic polymorphisms of MMPs have been found to be associated...

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Source

Identifiers

PMID: 22519450
DOI: 10.2174/1568026611208011206

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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