Article
A search for cyclophilin-A gene (PPIA) variation and its contribution to the risk of atherosclerosis and myocardial infarction.
International journal of immunogenetics - 1 Apr 2008
Palacín M, Rodríguez I, García-Castro M, Ortega F, Reguero J R, López-Larrea C, Morís C, Alvarez V, Coto E
Abstract excerpt
Cyclophilin A is secreted by vascular smooth muscle cells in response to inflammatory stimuli, and could thus contribute to atherosclerosis. We hypothesized that the genetic variation at the cyclophilin A gene (PPIA) could affect the risk for developing atherosclerosis and myocardial infarction. This study included 250 myocardial infarction patients (all male and < 60 years; 95% are smokers). All these cases had...
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