Article
Immunohistochemical analysis of polycyclic aromatic hydrocarbon-DNA adducts in breast tumor tissue.
Cancer letters - 30 Jun 2000
Santella R M, Gammon M D, Zhang Y J, Motykiewicz G, Young T L, Hayes S C, Terry M B, Schoenberg J B, Brinton L A, Bose S, Teitelbaum S L, Hibshoosh H
Abstract excerpt
Environmental carcinogens may play a role in the etiology of breast cancer, but the extent of their contribution is not yet defined. The aims of this study were to determine whether polycyclic aromatic hydrocarbon (PAH)-DNA adducts could be detected in stored paraffin blocks of breast tumor tissue (n=147) with an immunoperoxidase technique and whether they correlated with smoking history and/or mutant p53 protein...
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