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Article

Notch1 is a frequent mutational target in chemically induced lymphoma in mouse.

International journal of cancer - 1 Dec 2008

Karlsson Anneli, Ungerbäck Jonas, Rasmussen Anna, French John E, Söderkvist Peter

Abstract excerpt

Activating Notch1 mutations have been reported in human T-lineage acute lymphoblastic leukemia (T-ALL) and lymphomas from genetically modified mice. We report that Notch1 is a prevalent and major mutational target in chemically induced mouse lymphoma. The regions of the gene that are frequently m...

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PMID: 18798262
DOI: 10.1002/ijc.23832

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18798262-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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