Article
Interaction between HLA-DR2 and abnormal brain MRI in optic neuritis and early MS. Optic Neuritis Study Group.
Neurology - 9 May 2000
Hauser S L, Oksenberg J R, Lincoln R, Garovoy J, Beck R W, Cole S R, Moke P S, Kip K E, Gal R L, Long D T
Abstract excerpt
The association of the human leukocyte antigen (HLA)-DR2 allele with brain MRI signal abnormalities and with the development of MS was assessed in 178 patients enrolled in the Optic Neuritis Treatment Trial. HLA haplotype DR2 was present in 85 (48%) of the 178 patients. Its presence was associated with increased odds of probable or definite MS at 5 years (odds ratio, 1.92; 95% confidence interval, 1.01 to 3.67; p...
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