Article
Gene-environment interactions between HLA B7/A2, EBV antibodies are associated with MRI injury in multiple sclerosis.
Journal of neuroimmunology - 30 Apr 2009
Zivadinov Robert, Weinstock-Guttman Bianca, Zorzon Marino, Uxa Laura, Serafin Maurizia, Bosco Antonio, Bratina Alessio, Maggiore Cosimo, Grop Attilio, Tommasi Maria Antonietta, Srinivasaraghavan Bhooma, Ramanathan Murali
Abstract excerpt
PURPOSE: To determine the role of gene-environmental interactions between the Class I and Class II HLA alleles and the humoral anti-Epstein-Barr Virus (EBV) responses in the development of brain injury and clinical disability in multiple sclerosis (MS) patients. METHODS: A total of 93 MS patients (62 females; 31 males) and 122 healthy controls underwent HLA typing and testing for antibodies against EBV. The MS...
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