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Article

In-vitro selection of highly stabilized protein variants with optimized surface.

Journal of molecular biology - 8 Jun 2001

Martin A, Sieber V, Schmid F X

Abstract excerpt

Thermostable proteins are of prime importance in protein science, but it has remained difficult to develop general strategies for stabilizing a protein. Site-directed mutagenesis based on comparisons with thermophilic homologs is rarely successful because the sequence differences are too numerous and dominated by neutral mutations. Here we used a method of directed evolution to increase the stability of a...

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Source

Identifiers

PMID: 11397091
DOI: 10.1006/jmbi.2001.4698

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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