Article
The effects of ionic strength on protein stability: the cold shock protein family.
Journal of molecular biology - 31 May 2002
Dominy Brian N, Perl Dieter, Schmid Franz X, Brooks Charles L
Abstract excerpt
Continuum electrostatic models are used to examine in detail the mechanism of protein stabilization and destabilization due to salt near physiological concentrations. Three wild-type cold shock proteins taken from mesophilic, thermophilic, and hyperthermophilic bacteria are studied using these methods. The model is validated by comparison with experimental data collected for these proteins. In addition, a number...
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