Article
A common polymorphism acts as an intragenic modifier of mutant p53 behaviour.
Nature genetics - 1 May 2000
Marin M C, Jost C A, Brooks L A, Irwin M S, O'Nions J, Tidy J A, James N, McGregor J M, Harwood C A, Yulug I G, Vousden K H, Allday M J, Gusterson B, Ikawa S, Hinds P W, Crook T, Kaelin W G
Abstract excerpt
The p73 protein, a homologue of the tumour-suppressor protein p53, can activate p53-responsive promoters and induce apoptosis in p53-deficient cells. Here we report that some tumour-derived p53 mutants can bind to and inactivate p73. The binding of such mutants is influenced by whether TP53 (encoding p53) codon 72, by virtue of a common polymorphism in the human population, encodes Arg or Pro. The ability of...
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