Article
p53 codon 72 Arg homozygotes are associated with an increased risk of cutaneous melanoma.
The Journal of investigative dermatology - 1 Dec 2003
Shen Hongbing, Liu Zhensheng, Strom Sara S, Spitz Margaret R, Lee Jeffrey E, Gershenwald Jeffrey E, Ross Merrick I, Mansfield Paul F, Duvic Madeleine, Ananthaswamy Honnavara N, Wei Qingyi
Abstract excerpt
The p53 gene plays an important role in cell cycle control, facilitating DNA repair activities in response to DNA damage. Aberrant cell cycle control impairs DNA repair and increases the probability of mutations that can lead to carcinogenesis. The p53 gene is polymorphic at codon 72 (Arg/Pro) of its protein, which is functionally distinct, leading to inquiry into its role in carcinogenesis. In this...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.