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Article

Mutation of Ha-Ras C terminus changes effector pathway utilization.

The Journal of biological chemistry - 4 Aug 2000

Booden M A, Sakaguchi D S, Buss J E

Abstract excerpt

In PC12 cells, Ha-Ras modulates multiple effector proteins that induce neuronal differentiation. To regulate these pathways Ha-Ras must be located at the plasma membrane, a process normally requiring attachment of farnesyl and palmitate lipids to the C terminus. Ext61L, a constitutively activated and palmitoylated Ha-Ras that lacks a farnesyl group, induced neurites with more actin cytoskeletal changes and...

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Identifiers

PMID: 10801808
DOI: 10.1074/jbc.M001368200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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