Article
Rit, a non-lipid-modified Ras-related protein, transforms NIH3T3 cells without activating the ERK, JNK, p38 MAPK or PI3K/Akt pathways.
Oncogene - 28 Sept 2000
Rusyn E V, Reynolds E R, Shao H, Grana T M, Chan T O, Andres D A, Cox A D
Abstract excerpt
The biological functions of Rit (Ras-like protein in tissues) and Rin (Ras-like protein in neurons), members of a novel branch of Ras-related GTP-binding proteins that are approximately 50% identical to Ras, have not been characterized. Therefore, we assessed their activity in growth control, transformation and signaling. NIH cells stably expressing a constitutively activated mutant of Rit [Rit(79L)] (analogous...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.