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Article

Thymus aging in mice deficient in either EphB2 or EphB3, two master regulators of thymic epithelium development.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Oct 2020

García-Ceca Javier, Montero-Herradón Sara, Zapata Agustín G

Abstract excerpt

BACKGROUND: The epithelial microenvironment is involved in thymus aging, but the possible role of EphB receptors that govern the thymic epithelium development has not been investigated. Herein, we study the changes undergone by the thymus of EphB-deficient mice throughout their life. RESULTS: Immune alterations occurring throughout life were more severe in mutant than in wild-type (WT) mice. Mutant thymuses...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32506584
DOI: 10.1002/dvdy.212

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