Polyglutamine-induced ion channels: a possible mechanism for the neurotoxicity of huntington and other CAG repeat diseases

Abstract excerpt

CAG repeats resulting in long polyglutamine tracts have been implicated in the pathogenesis of at least eight neurodegenerative diseases including Huntington. Expression of polyglutamine repeats is required for disease and increasing length of the repeats leads to earlier onset of illness (anticipation). Expression of polyglutamine repeats in cultured neurons leads to deposition of intracellular aggregates...

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