Article
Frequent gain of the p40/p51/p63 gene locus in primary head and neck squamous cell carcinoma.
International journal of cancer - 1 Jun 2000
Yamaguchi K, Wu L, Caballero O L, Hibi K, Trink B, Resto V, Cairns P, Okami K, Koch W M, Sidransky D, Jen J
Abstract excerpt
We have identified a new human p53 homologue, p40 (p51/p63). This gene was mapped to the distal arm of 3q and was found to be essential for normal epithelial development. We used microsatellite and FISH analyses to search for genetic alterations of p40 in primary HNSCC. A more precise localization of p40 was completed using 6 known markers on 3q and a newly isolated microsatellite marker within the p40 gene. We...
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