Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

<i>AIS</i> is an oncogene amplified in squamous cell carcinoma

9 May 2000

Abstract excerpt

We and others recently isolated a human p53 homologue (p40/p51/p63/p73L) and localized the gene to the distal long arm of chromosome 3. Here we sought to examine the role of p40/p73L, two variants lacking the N-terminal transactivation domain, in cancer. Fluorescent in situ hybridization (FISH) analysis revealed frequent amplification of this gene locus in primary squamous cell carcinoma of the lung and head and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related gene regulation
Share to Cancer-related Molecular Pathways
Share to RNA modifications and cancer

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 10805802
DOI: 10.1073/pnas.97.10.5462

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

<i>AIS</i> is an oncogene amplified in squamous cell carcinomaPMID 10805802Read ↗

Frequent gain of the p40/p51/p63 gene locus in primary head and neck squamous cell carcinoma.Semantic proximity Read ↗

CREB3L4, INTS3, and SNAPAP are targets for the 1q21 amplicon frequently detected in hepatocellular carcinoma.Semantic proximity Read ↗

The expression of p73 is increased in lung cancer, independent of p53 gene alteration.Semantic proximity Read ↗

Identification of a novel retrovirus long terminal repeat (LTR) that is targeted by p51A (TAp63gamma) and selective dominant-negative activity of p73L (DeltaNp63alpha) toward p53-responsive promoter activities.Semantic proximity Read ↗

P73 expression in neuroblastoma: a role in the biology of advanced tumors?Semantic proximity Read ↗

p73: Friend or foe in tumorigenesis.Semantic proximity Read ↗

Tissue-specific MicroRNA Expression Alters Cancer Susceptibility Conferred by a <i>TP53</i> Noncoding VariantSemantic proximity Read ↗

Identification of an Integrated SV40 T/t-Antigen Cancer Signature in Aggressive Human Breast, Prostate, and Lung Carcinomas with Poor PrognosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.