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Article

Epidermal growth factor receptor expression in neurofibromatosis type 1–related tumors and NF1 animal models

1 May 2000

Abstract excerpt

We have found that EGF-R expression is associated with the development of the Schwann cell-derived tumors characteristic of neurofibromatosis type 1 (NF1) and in animal models of this disease. This is surprising, because Schwann cells normally lack EGF-R and respond to ligands other than EGF. Nevertheless, immunoblotting, Northern analysis, and immunohistochemistry revealed that each of 3 malignant peripheral...

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PMID: 10791998
DOI: 10.1172/jci7610

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