Article
Early-onset osteoarthritis linked to the type II procollagen gene. Detailed clinical phenotype and further analyses of the gene.
Arthritis and rheumatism - 1 Mar 1993
Vikkula M, Palotie A, Ritvaniemi P, Ott J, Ala-Kokko L, Sievers U, Aho K, Peltonen L
Abstract excerpt
OBJECTIVE: To specify in detail the clinical phenotype in 2 Finnish families demonstrating linkage between the type II procollagen gene (COL2A1) and osteoarthritis (OA). We also reevaluated the linkage and screened the exon sequences of the COL2A1 gene for mutations. METHODS: We used single-stran...
Topics
- Adolescent
- Adult
- Base Sequence
- DNA Mutational Analysis
- Electrophoresis, Polyacrylamide Gel
- Exons
- Female
- Genetic Linkage
- Humans
- Lod Score
- Male
- Middle Aged
- Molecular Sequence Data
- Oligonucleotide Probes
- Osteoarthritis
- Pedigree
- Phenotype
- Polymerase Chain Reaction