Article
Assessment of osteoarthritis candidate genes in a meta-analysis of nine genome-wide association studies.
Arthritis & rheumatology (Hoboken, N.J.) - 1 Apr 2014
Rodriguez-Fontenla Cristina, Calaza Manuel, Evangelou Evangelos, Valdes Ana M, Arden Nigel, Blanco Francisco J, Carr Andrew, Chapman Kay, Deloukas Panos, Doherty Michael, Esko Tõnu, Garcés Aletá Carlos M, Gomez-Reino Carnota Juan J, Helgadottir Hafdis, Hofman Albert, Jonsdottir Ingileif, Kerkhof Hanneke J M, Kloppenburg Margreet, McCaskie Andrew, Ntzani Evangelia E, Ollier William E R, Oreiro Natividad, Panoutsopoulou Kalliope, Ralston Stuart H, Ramos Yolande F, Riancho Jose A, Rivadeneira Fernando, Slagboom P Eline, Styrkarsdottir Unnur, Thorsteinsdottir Unnur, Thorleifsson Gudmar, Tsezou Aspasia, Uitterlinden André G, Wallis Gillian A, Wilkinson J Mark, Zhai Guangju, Zhu Yanyan, Felson David T, Ioannidis John P A, Loughlin John, Metspalu Andres, Meulenbelt Ingrid, Stefansson Kari, van Meurs Joyce B, Zeggini Eleftheria, Spector Timothy D, Gonzalez Antonio
Abstract excerpt
OBJECTIVE: To assess candidate genes for association with osteoarthritis (OA) and identify promising genetic factors and, secondarily, to assess the candidate gene approach in OA. METHODS: A total of 199 candidate genes for association with OA were identified using Human Genome Epidemiology (HuGE) Navigator. All of their single-nucleotide polymorphisms (SNPs) with an allele frequency of >5% were assessed by...
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