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Article

Evidence for an RNA-based catalytic mechanism in eukaryotic nuclear ribonuclease P.

RNA (New York, N.Y.) - 1 Apr 2000

Thomas B C, Chamberlain J, Engelke D R, Gegenheimer P

Abstract excerpt

Ribonuclease P is the enzyme responsible for removing the 5'-leader segment of precursor transfer RNAs in all organisms. All eukaryotic nuclear RNase Ps are ribonucleoproteins in which multiple protein components and a single RNA species are required for activity in vitro as well as in vivo. It is not known, however, which subunits participate directly in phosphodiester-bond hydrolysis. The RNA subunit of nuclear...

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Identifiers

PMID: 10786846
DOI: 10.1017/s1355838200991477
PMCID: PMC1369936

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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