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Article

Structure-function analysis in nuclear RNase P RNA.

Molecular biology reports - 1 Jan 2000

Engelke D R, Pagán-Ramos E, Tranguch A J

Abstract excerpt

Eukaryotic ribonuclease P (RNase P) enzymes require both RNA and protein subunits for activity in vivo and in vitro. We have undertaken an analysis of the complex RNA subunit of the nuclear holoenzyme in an effort to understand its structure and its similarities to and differences from the bacterial ribozymes. Phylogenetic analysis, structure-sensitive RNA footprinting, and directed mutagenesis reveal conserved...

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PMID: 8901504
DOI: 10.1007/BF00988722

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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