Article
[Progress of research on protein composition and gene therapy of Fanconi anaemia - review].
Zhongguo shi yan xue ye xue za zhi - 1 Apr 2004
Li Zai-Yi, Zou Yi-Feng, Deng Yu-Bin
Abstract excerpt
Fanconi anaemia (FA) is an autosomal recessive inherited disorder caused by defects in hematopoietic stem cells. The clinical manifestations of FA are diverse and complicated. FA cells display high hypersensitivity to agents which produce interstrand DNA cross-links such as mitomycin C (MMC) or diepoxybutane (DEB). At least eight complementation groups with defects in eight genes (FANCA, FANCB, FANCC, FANCD(1),...
Topics
- Cell Cycle Proteins
- DNA-Binding Proteins
- Fanconi Anemia
- Fanconi Anemia Complementation Group C Protein
- Fanconi Anemia Complementation Group D2 Protein
- Fanconi Anemia Complementation Group Proteins
- Genetic Therapy
- Hematopoietic Stem Cell Transplantation
- Humans