Article
Congenital disorders sharing oxidative stress and cancer proneness as phenotypic hallmarks: prospects for joint research in pharmacology.
Medical hypotheses - 1 Sept 1998
Pagano G, Korkina L G, Brunk U T, Chessa L, Degan P, del Principe D, Kelly F J, Malorni W, Pallardó F, Pasquier C, Scovassi I, Zatterale A, Franceschi C
Abstract excerpt
In spite of very distinct genotypic assets, a number of congenital conditions include oxidative stress as a phenotypic hallmark. These disorders include Fanconi's anaemia, ataxia telangiectasia, xeroderma pigmentosum and Bloom's syndrome, as well as two frequent congenital conditions: Down's syndrome and cystic fibrosis. Cancer proneness is a clinical feature shared by these disorders, while other manifestations...
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