Article
Re-definition and supporting evidence toward Fanconi Anemia as a mitochondrial disease: Prospects for new design in clinical management.
Redox biology - 1 Apr 2021
Pagano Giovanni, Tiano Luca, Pallardó Federico V, Lyakhovich Alex, Mukhopadhyay Sudit S, Di Bartolomeo Paolo, Zatterale Adriana, Trifuoggi Marco
Abstract excerpt
Fanconi anemia (FA) has been investigated since early studies based on two definitions, namely defective DNA repair and proinflammatory condition. The former definition has built up the grounds for FA diagnosis as excess sensitivity of patients' cells to xenobiotics as diepoxybutane and mitomycin C, resulting in typical chromosomal abnormalities. Another line of studies has related FA phenotype to a prooxidant...
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