The N-terminal hydrophobic domain of P450c21 is required for membrane insertion and enzyme stability.

Article

The N-terminal hydrophobic domain of P450c21 is required for membrane insertion and enzyme stability.

The Journal of biological chemistry - 15 Jul 1993

Hsu L C, Hu M C, Cheng H C, Lu J C, Chung B C

Abstract excerpt

Microsomal cytochromes P-450 are known to be integrated into smooth endoplasmic reticulum through their hydrophobic sequences located at the N termini. The length requirement of the membrane insertion signal was determined by the generation of six plasmids encoding mutant P450c21 that lacked vari...

Topics

Animals
Biological Transport
Dogs
Enzyme Stability
Humans
Intracellular Membranes
Microsomes
Mutation
Protein Biosynthesis
Sequence Deletion
Steroid 21-Hydroxylase

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