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Article

Single nucleotide polymorphism in 5'-flanking region reduces transcription of surfactant protein B gene in H441 cells.

American journal of physiology. Lung cellular and molecular physiology - 1 Sept 2006

Thomas Klaus H, Meyn Philipp, Suttorp Norbert

Abstract excerpt

Surfactant protein (SP)-B is expressed in a cell-specific manner and is essential for surfactant function and survival. Abnormal surfactant function occurs in humans and genetically engineered mice with SP-B levels well below 50% of normal. SP-B mRNA levels vary in fetal lung explants among individuals, possibly due to genetic variety. Polymorphisms within the SP-B gene have been described extensively; however,...

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PMID: 16500948
DOI: 10.1152/ajplung.00193.2005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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