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Article

Analysis of genomic regions involved in regulation of the rabbit surfactant protein A gene in transgenic mice.

The American journal of physiology - 1 Aug 1999

Alcorn J L, Hammer R E, Graves K R, Smith M E, Maika S D, Michael L F, Gao E, Wang Y, Mendelson C R

Abstract excerpt

The gene encoding surfactant protein (SP) A, a developmentally regulated pulmonary surfactant-associated protein, is expressed in a lung-specific manner, primarily in pulmonary type II cells. SP-A gene transcription in the rabbit fetal lung is increased by cAMP. To delineate the genomic regions involved in regulation of SP-A gene expression, lines of transgenic mice carrying fusion genes composed of various...

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Identifiers

PMID: 10444530
DOI: 10.1152/ajplung.1999.277.2.L349

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