Article
TGT3, thyroid transcription factor I, and Sp1 elements regulate transcriptional activity of the 1.3-kilobase pair promoter of T1alpha, a lung alveolar type I cell gene.
The Journal of biological chemistry - 17 Oct 1997
Ramirez M I, Rishi A K, Cao Y X, Williams M C
Abstract excerpt
Alveolar type I epithelial cells form the major surface for gas exchange in the lung. To explore how type I cells differ in gene expression from their progenitor alveolar type II cells, we analyzed transcriptional regulation of T1alpha, a gene expressed by adult type I but not type II cells. In v...
Topics
- Adult
- Animals
- Base Sequence
- Cell Line, Transformed
- Cloning, Molecular
- DNA
- Humans
- Molecular Sequence Data
- Mutagenesis
- Nuclear Proteins
- Phenotype
- Promoter Regions, Genetic
- Protein Binding
- Pulmonary Alveoli
- Rats
- Sp1 Transcription Factor
- Thyroid Nuclear Factor 1
- Transcription Factors