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Article

Uterine leiomyosarcomas with osteoclast-like giant cells associated with high expression of RUNX2 and RANKL.

Virchows Archiv : an international journal of pathology - 1 May 2021

Terasaki Mika, Terasaki Yasuhiro, Wakamatsu Kyoko, Kuwahara Naomi, Yoneyama Koichi, Kawase Rieko, Kurose Keisuke, Toda Etsuko, Endo Yoko, Kunugi Shinobu, Kajimoto Yusuke, Shimizu Akira

Abstract excerpt

Uterine leiomyosarcoma (ULMS) with osteoclast-like giant cells (OLGCs) has been reported as a rare phenomenon in ULMS, and its clinico-pathological features and tumorigenesis remain unclear. We recently reported high expression of receptor activator of nuclear factor κB ligand (RANKL) in ULMS with OLGCs. As osteoblasts produce RANKL, in this study, we analyzed the expression of Runt-related transcription factor 2...

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PMID: 33404854
DOI: 10.1007/s00428-020-02996-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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