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Article

Effect of fluvoxamine therapy on the activities of CYP1A2, CYP2D6, and CYP3A as determined by phenotyping.

Clinical pharmacology and therapeutics - 1 Sept 1998

Kashuba A D, Nafziger A N, Kearns G L, Leeder J S, Gotschall R, Rocci M L, Kulawy R W, Beck D J, Bertino J S

Abstract excerpt

OBJECTIVE: To determine the effect of 150 mg/day fluvoxamine on the activities of CYP1A2, CYP2D6, CYP3A, N-acetyltransferase-2 (NAT2), and xanthine oxidase (XO) by phenotyping with caffeine, dextromethorphan, and midazolam. METHODS: Oral caffeine (2 mg/kg), oral dextromethorphan (30 mg), and intravenous midazolam (0.025 mg/kg) were administered to 10 white male volunteers every 14 days for 4 months and to 10...

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Identifiers

PMID: 9757149
DOI: 10.1016/S0009-9236(98)90174-6

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NAT2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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