Effect of fluvoxamine therapy on the activities of CYP1A2, CYP2D6, and CYP3A as determined by phenotyping.

doi:10.1016/S0009-9236(98)90174-6

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Article

Effect of fluvoxamine therapy on the activities of CYP1A2, CYP2D6, and CYP3A as determined by phenotyping.

Clinical pharmacology and therapeutics - 1 Sept 1998

Kashuba A D, Nafziger A N, Kearns G L, Leeder J S, Gotschall R, Rocci M L, Kulawy R W, Beck D J, Bertino J S

Abstract excerpt

OBJECTIVE: To determine the effect of 150 mg/day fluvoxamine on the activities of CYP1A2, CYP2D6, CYP3A, N-acetyltransferase-2 (NAT2), and xanthine oxidase (XO) by phenotyping with caffeine, dextromethorphan, and midazolam. METHODS: Oral caffeine (2 mg/kg), oral dextromethorphan (30 mg), and intr...

Topics

Acetyltransferases
Adult
Anti-Anxiety Agents
Antitussive Agents
Aryl Hydrocarbon Hydroxylases
Caffeine
Central Nervous System Stimulants
Cytochrome P-450 CYP1A2 Inhibitors
Cytochrome P-450 CYP2D6 Inhibitors
Cytochrome P-450 CYP3A
Cytochrome P-450 Enzyme Inhibitors
Dextromethorphan
Female

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Fluvoxamine

Genotype

Humans

Hypnotics and Sedatives

Male

Source

Open in PubMed

Identifiers

PMID: 9757149
DOI: 10.1016/S0009-9236(98)90174-6

Genes

NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9757149-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.