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Article

Use of midazolam urinary metabolic ratios for cytochrome P450 3A (CYP3A) phenotyping.

Pharmacogenetics - 1 Jun 2001

Streetman D S, Kashuba A D, Bertino J S, Kulawy R, Rocci M L, Nafziger A N

Abstract excerpt

Midazolam (MDZ) total clearance (ClT) is widely used for cytochrome P450 3A (CYP3A) phenotyping, but requires up to eight blood samples. This study was conducted to compare the use of midazolam ClT to use of a midazolam urinary metabolic ratio for CYP3A phenotyping. Ten male and 10 female subjects received i.v. midazolam 0.025 mg/kg eight times over a 4-month period at approximately 2-week intervals. The first...

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Share to Aryl Hydrocarbon Hydroxylases
Share to Cytochrome P-450 CYP3A

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cytochrome P-450 Enzyme Inhibitors

Share to Cytochrome P-450 Enzyme System

Share to Fluvoxamine

Share to Metabolic Clearance Rate

Share to Midazolam

Share to Oxidoreductases, N-Demethylating

Source

Identifiers

PMID: 11434513
DOI: 10.1097/00008571-200106000-00010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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