Article
Overexpression of the hOGG1 gene and high 8-hydroxy-2'-deoxyguanosine (8-OHdG) lyase activity in human colorectal carcinoma: regulation mechanism of the 8-OHdG level in DNA.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Apr 2000
Kondo S, Toyokuni S, Tanaka T, Hiai H, Onodera H, Kasai H, Imamura M
Abstract excerpt
8-Hydroxy-2'-deoxyguanosine (8-OHdG) is one of the most abundant oxidatively modified lesions in DNA. Our previous study (Kondo et al, Free Radic. Biol. Med., 27: 401-410, 1999) revealed that human colorectal carcinoma cells are oxidatively stressed based on 8-OHdG determination. To elucidate 8-O...
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