Article
8-Hydroxy-2'-deoxyguanosine (8-OH-dG) as a potential survival biomarker in patients with nonsmall-cell lung cancer.
Cancer - 1 Feb 2007
Shen Jie, Deininger Prescott, Hunt Jay D, Zhao Hua
Abstract excerpt
BACKGROUND: 8-Hydroxy-2'-deoxyguanosine (8-OH-dG) is 1 of the most abundant oxidative products of cellular DNA. Accumulation of impaired 8-OH-dG could lead to increased genomic instability that in turn could lead to a more malignant phenotypic behavior of tumors. Therefore, the effects of 8-OH-dG...
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