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Functional polymorphisms of the hOGG1 gene confer risk to type 2 epithelial ovarian cancer in Chinese.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society - 1 Nov 2011

Chen Xiaoxiang, Liu Xiufang, Wang Jingmei, Guo Wenwen, Sun Caixia, Cai Zhenming, Wu Qiang, Xu Xia, Wang Yaping

Abstract excerpt

OBJECTIVE: 8-Hydroxydeoxyguanosine (8-OHdG) is an oxidized nucleoside that can lead to misincorporation of bases. Human 8-oxoguanine DNA glycosylase (hOGG1) is the key defense enzyme against mutation by the cellular 8-OHdG in duplex DNA. The present study was aimed to explore whether the hOGG1 gene variants play an important role in the carcinogenesis of epithelial ovarian cancer (EOC). METHODS: Germ line...

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PMID: 21997177
DOI: 10.1097/IGC.0b013e31823122c6

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