Article
Intergenic complementation truncation mutants of cyclin-dependent kinase.
Molecular & general genetics : MGG - 1 Mar 2000
Bitter G A, Tsai M M, Putzke A P, Leong K
Abstract excerpt
The Saccharomyces cerevisiae genes PHO80 and PHO85 encode, respectively, a cyclin and cyclin-dependent kinase, which negatively regulate PHO5 gene transcription by phosphorylating the transcription activator Pho4p. Cyclin-dependent kinases (CDKs) are highly conserved proteins, both within and between species. It was previously demonstrated, using reporter genes activated in yeast by Pho4p, that hybrid proteins in...
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