Article
Requirement of the Caenorhabditis elegans RapGEF pxf-1 and rap-1 for epithelial integrity.
Molecular biology of the cell - 1 Jan 2005
Pellis-van Berkel W, Verheijen M H G, Cuppen E, Asahina M, de Rooij J, Jansen G, Plasterk R H A, Bos J L, Zwartkruis F J T
Abstract excerpt
The Rap-pathway has been implicated in various cellular processes but its exact physiological function remains poorly defined. Here we show that the Caenorhabditis elegans homologue of the mammalian guanine nucleotide exchange factors PDZ-GEFs, PXF-1, specifically activates Rap1 and Rap2. Green fluorescent protein (GFP) reporter constructs demonstrate that sites of pxf-1 expression include the hypodermis and gut....
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