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Article

cAMP–Epac2‐mediated activation of Rap1 in developing male germ cells: RA‐RhoGAP as a possible direct down‐stream effector

20 Oct 2008

Abstract excerpt

Rap1 is a small GTPase that functions as a positional signal and organizer of cell architecture. Recently Rap1 is emerged to play a critical role during sperm differentiation since its inactivation in haploid cells leads to a premature release of spermatids from the supporting Sertoli cell resulting in male infertility. How Rap1 is activated in spermatogenic cells has not yet been determined. Our objective was to...

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PMID: 18937323
DOI: 10.1002/mrd.20963

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Related research

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cAMP–Epac2‐mediated activation of Rap1 in developing male germ cells: RA‐RhoGAP as a possible direct down‐stream effectorPMID 18937323Read ↗

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Rho family GTPase Rnd2 interacts and co-localizes with MgcRacGAP in male germ cellsSemantic proximity Read ↗

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